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Thanks for the breakdown.
And Your Reward Is Clothes: Handled differently from the mainline titles. The player has to collect various articles of clothing before they get the chance use a character's alternate outfit. Another Side, Another Story: The game's levels are not in chronological order and while the first level of J's Bar is the starting point, the survivors split up and some levels take place at the same time as others.
For example, a certain group of survivors make their way from J's Bar to the Apple Inn that is on fire in the level Hellfire. Around the time this is happening, another group of survivors made their way through Outbreak's proper level culminating in the explosive detonation on Main Street. The more clearly defined case would be the final levels of File 1 and 2.
After creating the cure, he escapes on a helicopter. Both levels end with the same explosion that levels Raccoon City. Some levels will offer alternate options to completing them, should you fail initially. Failed to escape onto the subway car? You'll have to detour towards the maintenance system.
Did the bridge snap before you can cross it? A new quest has been unlocked so you can finish that instead! Did not get to the helicopter on time? Looks like you will have to fight the final boss after all. Four players online, one player and two AI partners offline. The partner AIs in the original seem to have a brain.
For example, they will help you push objects if they see you struggling and they will often go to find key items for you in the last two scenarios. Unfortunately, the AIs in File 2 are dumber than Swiss cheese. They will refuse to help you push heavy objects. They often stand next to zombies and challenge them to a staring contest while said zombies try to feast on whatever nutrition there is in those tiny brains.
In the last scenario, they think nothing of walking onto claymore mines or standing in an open area getting repeatedly sniped. Attack of the Foot Whatever: Titan, the Elephant Zombie. However, it can be locked in a trap. The rocket launcher required your target to be either stand still or come at a slow pace. You had one shot. You have to be in arms length, and hold the button for about five seconds before it will actually blow up Mr.
That is assuming he didn't just walk away from its range. Not as extreme as the characters from the main games, but they were all badass enough to survive Raccoon City.
Special mention goes to the blonde cop Raymond, an NPC who doesn't survive but dies yelling for you to "Burn these bastards! In a way, you have to give the Axe man some props. He's almost as normal as the survivors, has only a fire axe, and will take on the players, no matter how well armed they are.
The only time he finally relents is when you defeat him at the end of the level. When she dies, her corpse still has her extra item slots. One common cheat for beating "Desperate Times" on the hardest setting is to deliberately kill Yoko in the RPD courtyard, then use her body as an ammo dump. It's not absolutely necessary, but it makes things a lot easier for all but the most skilled players.
For some reason, J's Bar has its storeroom and loading dock on the third floor, and has no freight elevator to get those massive wine casks to the bar area. There's a canal in the bottom floor of the Raccoon City Hospital. File 2 has the three unlockable Elimination scenarios, with different areas conjoined together, with only one objective. Kill everything that moves before the time expires.
In addition, you can also unlock three Showdown scenarios. One lets you fight all the bosses from Outbreak not counting the hordes of zombies. Two pits you against all the bosses from File 2. The third has all the games bosses! Beating all those bosses has you take on two Mr. Xs, plus a red, more powerful and faster Mr. Half way in, the player comes across the front of a relatively safe Apple Inn, and will be transported to main street.
End of the Road concludes with the player having a chance depending on the location, or if you are playing single player as it is pre-determined by character of starting at the front of the Apple Inn, OR at Main Street. How does the game end?
With you escorting another fellow survivor. An unlockable extra mode. Breakable Weapons Breaking the Fourth Wall: If you hide from a zombie in a locker before it sees you, it will stumble around and leave.
If you open up the minimap while it is still there, however, it will "hear" it and attack. Bribing Your Way to Victory: Late in the game's life cycle, players who had purchased backwards compatible PlayStation 3 s were able to play online with PS2 users. If you dawdle too long before crossing the rope bridge in "Flashback", it will crumble. This opens up a separate sidequest, however, which you could only play online.
Thankfully, for the North American version, the sidequest is available offline. Remember the "Licker in the Window" jump scare from Resident Evil 2? Yeah, now it's back. Nicholai, The Mole from Resident Evil 3: Nemesis appears in the last mission of the original Outbreak , stealing blood from Thanatos and killing its creator. Leon and Claire, the protagonists from Resident Evil 2 , are shown passing by the van at Kevin's ending of Desperate Times.
In Outbreak , there is one camera angle that gives almost every player fits. The first floor of the apartment building next to J's Bar is a low angle shot that ruins your perspective. Naturally there are three zombies and a hard time limit to get through it. Many players can navigate it by rote, but that only works if you're the first one through. There are zombies bashing on the front doors, the doctors are gone, the halls are filled with bloodstains and corpses.
The first thing the last surviving doctor says is "This hospital is not as safe as it may look or sound. That Daylight Vaccine is very useful for curing you of the T-virus. It is also your means to instantly kill the final boss or at least deal a large amount of damage to it , should you use it with the injection gun.
The bomb that was implanted inside Mr. X in End of the Road. If you haven't activated it yet, and have to face Nyx, you have the opportunity to deal a great deal of damage on him. Part of the reason the Outbreak games are canonically disputed is that the characters have never been seen again not that undisputedly canon characters haven't also dropped out of the plot.
Not even Yoko, who got the most character development and has ties to Umbrella, and uses it to testify with obviously damaging results against Umbrella in the aftermath, helping its downfall.
Reportedly, the only way Capcom was able to sidestep their Nintendo exclusivity contract was to make the non-Nintendo games non-canon. Also subverted by the series' latest entry, where one of the eight playable characters is mentioned in a file. In "End of the Road," an Umbrella sniper brags about killing zombies and shoots Linda and the player who are clearly human for no good reason. Raccoon City is also destroyed substantially earlier in both Outbreak games than it is in the ending of RE3.
If you're knocked down, you are denied access to any weapons until you were pulled back to your feet by another character, or you use a health item. However, you can crawl around on the ground to try and evade danger. File 2 allows you to collect items while you are down, which means you can get back up if a first aid spray happens to be laying around. If your connection were to drop during an online game, you'd keep playing, but all of the other players' characters would suddenly, simultaneously drop dead.
Likewise, if you quit out of a game, the game treated it as though you'd suddenly died. Areas from these games were recycled for use in The Umbrella Chronicles. Cutting Off the Branches: As of Resident Evil 7: The fates of the other playable characters are left unknown. On by default, although some servers allowed player-killing. At random intervals in the "Desperate Times" scenario, gas will be pumped into the room that speeds up your infection rate until you leave or use an anti-gas canister.
It's even a sickly yellow color. Department of Redundancy Department: Outbreak contains a scenario called "Outbreak" that details the first stages of a viral outbreak. Do Not Run with a Gun: Not so with File 1 , obviously. Duct Tape for Everything: David can create some unique weapons using the duct tape in his tool belt along with the right implements.
Dying Moment of Awesome: Raymond the blonde cop does not go quietly. After being knocked down by a zombie, which begins eating him, he gives the player a lighter and alerts them to a nearby gasoline tanker, yelling for them to unleash the gas and burn up the zombies and himself! That's a fuel tank! Leak the gas and use it to kill these bastards! Ran out of ammo? Your melee weapons broke off? Left all those knives behind? Time to start tackling and stomping! Escape from the Crazy Place: Starting off the Outbreak scenario with anyone playing as Mark has Bob, who cannot move properly without help.
Thankfully, this is optional, as the player could simply leave him to his fate. It was either that, or escort him to earn points, but ending with him either shooting himself, or becoming a zombie.
Zigzagged in End of the Road. This doesn't last long. That too is optional, unless you want the good ending. No more pools of blood to inform you that a creature is completely dead; now it just vanishes. Carter tries to use one on a Tyrant in "End of the Road" and the player can later collect the remote to skip a fight with it. If the Leech Man kills a character, he or she will be resurrected a while later as another Leech Man that can't be killed in the same way the regular Leech Man needs to be.
In Outbreak , we have Thanatos, an upgraded Tyrant, who is the last enemy the characters have to defeat to escape the city. In File 2 , if the players failed to escape the city via transport helicopter, they will be forced to face Nyx , who makes it's introduction by effortlessly slaughtering the UBCS mercenaries , making Thanatos look like a wimp! Once you do go to finally face him, he is then seen devouring a mutated Mr.
Raccoon City's getting nuked. Hope the characters got out of range! The Outbreak series has kind of a shaky relationship with canon. It was originally stated to be a sidestory with no bearing on the main plot, but aside from a few minor issues, there was no reason why it couldn't have been set in the main continuity. A couple of scenarios and locations from the Outbreak games appeared as what were essentially Easter eggs in a couple of scenarios in The Umbrella Chronicles , and Ada's bonus chapter is essentially a very quick retelling of "End of the Road" from File 2.
Fast forward to the modern day, and the "Daylight" vaccine from the first Outbreak apparently figures into the plot of the Resident Evil 6 manga. A player-controlled Alyssa using her ad-libs can cause File 1 to lock up. Getting Crap Past the Radar: In-Universe, there's a pamphlet you can find in Wild Things promoting a show with a lion named Max the final boss, Stalker and two other lionesses.
The pamphlet is basically Max telling the kids he's getting two new "fine felines" and at the end, he asks the kids to give 'em some "privacy. Not that you'll see it unless you meddle with the files. Just try to find the invisible special items which are necessary for unlocking costumes and special features without a guide.
Some of these criteria include killing yourself in specific ways. Alyssa's lockpick combinations, the game gives absolutely no indication of which one to use. Now, you can either read a guide or try killing yourself by spending some minutes trying to find the correct one. Some of the puzzles on the game are just Insane Troll Logic.
For example, the password for the elevator in The Hive is supposed be found on a random background object, which upon examination will say "There is an event scheduled for September The combination for the safe puzzle on Underbelly is found in a two-page file, both pages containing nothing but a bunch of scrambled letters, and you have to make a four-number combination out of it.
Good luck with that. He Knows About Timed Hits: I Can't Reach It: The entire first half of the level "Outbreak" requires players to escape to the roof, jump between buildings, and come down the the building next door into the street in front.
Even if you kill all the zombies coming into the bar, the game does not let you walk right out the front door to reach the same spot. The games love using this one.
Roughly half the levels have some monstrous bullet-sponge stalking you the entire time. Special points to the Final Boss , Thanatos, who never actually dies until the nuclear missile falls. The characters can only incapacitate him temporarily.
Yoko starts Outbreak 's events by trimming her hair, as a sign of putting her past behind her. Also because Outbreak occurs canonically a few days after her old boss, William Birkin, was machine-gunned by HUNK and friends to cover things up.
Changing your appearance is a pretty good idea in that situation. Push brooms, bent pipes, crutches, nail guns In the Outbreak scenario, there will be a cutscene where you'll be placed in a police van. The officer drives the van for a short while, and then he stops because there is a pair of small barriers in the way and tells you to go on foot.
Luckily, the survivors are smart enough to not let themselves be stopped by this, when they get a chance at driving a truck in End of the Road , they just use it to knock some barriers down and escape the city. Kurt, whose files are read and story uncovered in "Flashback".
Oh so very much, especially offline. Yoko often alleviates this problem. January 16, ; Accepted Date: January 20, ; Published date: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Internal Medicine: A 3 year, multicenter, observational cohort study was performed. DISC were compared with those who maintained the same dose of MTX after achieving clinical remission maintained group: Rheumatoid arthritis ; Methotrexate; Tocilizumab; Michinoku; Observational cohort study.
Methotrexate MTX is considered as an anchor drug because of its effectiveness and general versatility in the treatment of rheumatoid arthritis RA [ 1 ]. The data suggest that both TCZ add-on and switch strategies led to meaningful clinical and radiographic responses, despite a trend favoring the add-on strategy [ 8 ]. Both studies noted that the combination with MTX increased adverse events such as gastrointestinal disorders , respiratory, thoracic and mediastinal disorders, and laboratory test abnormalities.
The target of treatment of RA is clinical remission . This study was a multicenter, prospective, observational, noninterventional, cohort study performed by the MTSG [ 11 ]. The patients were screened following the guideline of the Japan College of Rheumatology, and comorbidity was treated or controlled before administration of TCZ in order to prevent adverse events.
In total, patients with RA who started TCZ therapy were followed and patients successfully completed 36 month observational period. The patients were treated by TCZ with or without MTX at the beginning of this study according to the decision of the attending physician in actual clinical practice. Thirty-seven patients, whose MTX doses were not precisely determined at the beginning or during the 36 month observational period, were excluded from patients and patients were analyzed in this study.
The dose of MTX depended on the discretion of the attending physician as well. The MTX doses and disease activities were precisely observed during 36 month observational period, and were classified into 4 groups by means of the MTX doses at the end of the observational period as follows: The patient disposition and study flow chart is shown in Figure 1.
Patient disposition and study flow chart TCZ: This study was approved by the Ethics Committee of Tohoku University and of each medical institution. All participants gave their written informed consent. The period to discontinue MTX after remission was demonstrated in Table 1. Those at 3 months were 1. The remission rates determined by the Boolean definition at 6 months were Adverse events were classified by system organ class of the Medical Dictionary for Regulatory Activities version There were no significant differences in adverse events between them.